How does chronic inflammation contribute to cancer development?

Chronic inflammation plays a significant role in cancer development mainly by creating a microenvironment that supports cellular proliferation. Inflammatory processes can lead to an increase in the production of growth factors, cytokines, and enzymes, which can cause alterations in tissue architecture and promote the survival of damaged cells.

These factors can drive the proliferation of cells that may become cancerous over time, as the constant inflammatory signals can lead to mutations and genomic instability. This microenvironment can support not just the growth of cancer cells but also their ability to invade surrounding tissues and metastasize to other parts of the body.

In summary, the persistent state of inflammation fosters conditions that allow for uncontrolled cell growth and survival, ultimately contributing to the initiation and progression of cancer.